Unchanged [H]ouabain binding site content but reduced Na -K pump 2-protein abundance in skeletal muscle in older adults
نویسندگان
چکیده
Michael J. McKenna, Ben D. Perry, Fabio R. Serpiello, Marissa K. Caldow, Pazit Levinger, David Cameron-Smith, and Itamar Levinger Institute of Sport, Exercise and Active Living (ISEAL), Muscle, Ions and Exercise Group, Victoria University, Melbourne, Victoria, Australia; School of Sport and Exercise Science, Muscle, Ions and Exercise Group, Victoria University, Melbourne, Victoria, Australia; Facolta’ di Scienze Motorie, Universita’ degli Studi di Verona, Verona, Italy; School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Victoria, Australia; and Liggins Institute, University of Auckland, Auckland, New Zealand
منابع مشابه
Effects of Age on Na+,K+-ATPase Expression in Human and Rodent Skeletal Muscle
The maintenance of transmembrane Na(+) and K(+) concentration gradients and membrane potential is vital for the production of force in skeletal muscle. In aging an inability to maintain ion regulation and membrane potential would have adverse consequences on the capacity for performing repeated muscle contractions, which are critical for everyday activities and functional independence. This sho...
متن کاملIntense interval training in healthy older adults increases skeletal muscle [3H]ouabain‐binding site content and elevates Na+,K+‐ATPase α2 isoform abundance in Type II fibers
Young adults typically adapt to intense exercise training with an increased skeletal muscle Na+,K+-ATPase (NKA) content, concomitant with reduced extracellular potassium concentration [K+] during exercise and enhanced exercise performance. Whether these changes with longitudinal training occur in older adults is unknown and was investigated here. Fifteen older adults (69.4 ± 3.5 years, mean ± S...
متن کاملGlucocorticoids increase sodium pump a2- and b1-subunit abundance and mRNA in rat skeletal muscle
Thompson, Curtis B., Inge Dorup, Julie Ahn, Patrick K. K. Leong, and Alicia A. McDonough. Glucocorticoids increase sodium pump a2and b1-subunit abundance and mRNA in rat skeletal muscle. Am J Physiol Cell Physiol 280: C509–C516, 2001.—Fourteen-day adrenal steroid treatment increases [H]ouabain binding sites 22–48% in muscle biopsies from patients treated with adrenal steroids for chronic obstru...
متن کاملEffects of age and exercise training on Na+-K+ pumps in skeletal muscle.
THE EFFECTS OF AGE AND EXERCISE training on the content of Na -K -ATPase (Na -K pumps) in skeletal muscle have been characterized by several laboratories in at least seven different species (for review, see Ref. 1). In the rat, Na -K pumps as quantified by measuring the capacity for [3H]ouabain binding to intact skeletal muscle were shown to increase from birth and to reach a maximum at 1 mo of...
متن کاملPotassium depletion increases potassium clearance capacity in skeletal muscles in vivo during acute repletion.
Muscular K uptake depends on skeletal muscle Na-K-ATPase concentration and activity. Reduced K uptake is observed in vitro in K-depleted rats. We evaluated skeletal muscle K clearance capacity in vivo in rats K depleted for 14 days. [(3)H]ouabain binding, alpha(1) and alpha(2) Na-K-ATPase isoform abundance, and K, Na, and Mg content were measured in skeletal muscles. Skeletal muscle K, Na, and ...
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تاریخ انتشار 2012